HER2 IHC Summary
Notes
**Note 1:** Physician statement of HER2 IHC Summary can be used to code this data item when no other information is available.
**Note 2:** The HER2 IHC test performed on the primary breast tissue is to be recorded in this data item.
**Note 3:** Results from nodal or metastatic tissue may be used, ONLY when there is no evidence of primary tumor.
**Note 4:** In cases where HER2 IHC is reported on more than one breast tumor specimen, record the highest value. If any sample is positive, record as positive.
**Note 5:** If neoadjuvant therapy is given, record the assay from tumor specimens prior to neoadjuvant therapy.
* If neoadjuvant therapy is given and there are no HER2 IHC results from pre-treatment specimens, report the findings from post-treatment specimens.
**Note 6:** If HER2 IHC is positive on an in situ specimen and HER2 IHC is negative on all tested invasive specimens, code HER2 IHC as negative (code 0).
**Note 7:** A 2+ (equivocal) finding by IHC should result in additional testing with ISH to determine gene copy number.
**Note 8:** An immunohistochemistry (IHC) test identifies the protein expressed by the gene (ERBB2), and an in situ hybridization (ISH) test identifies the number of copies of the gene (ERBB2) itself.
Default
8
Metadata
SSDI
| Code |
Description |
| 0 |
Negative (Score 0) |
| 1 |
Negative (Score 1+) |
| 2 |
Equivocal (Score 2+)
Stated as equivocal |
| 3 |
Positive (Score 3+)
Stated as positive |
| 4 |
Stated as negative, but score not stated |
| 7 |
Test ordered, results not in chart |
| 8 |
Not applicable: Information not collected for this case
(If this item is required by your standard setter, use of code 8 will result in an edit error.) |
| 9 |
Not documented in medical record
Cannot be determined (indeterminate)
HER2 IHC Summary not assessed or unknown if assessed |
