Grade Pathological


**Note 1:** Pathological grade must not be blank. **Note 2:** Assign the highest grade from the primary tumor. If the clinical grade is higher than the grade determined during the pathological time frame, use the grade that was identified during the clinical time frame for both the clinical grade and the pathological grade. **Note 3:** Codes 1-4 take priority over A-D, L and H. **Note 4:** CNS WHO classifications use a grading scheme that is a “malignancy scale” ranging across a wide variety of neoplasms rather than a strict histologic grading system that can be applied equally to all tumor types. * Code the WHO grading system for selected tumors of the CNS as noted in the AJCC 8th edition Table 72.2 where WHO grade is not documented in the record **Note 5:** Code 9 when * Grade from primary site is not documented * No resection of the primary site * Neo-adjuvant therapy is followed by a resection (see post-therapy grade) * Clinical case only (see clinical grade) * There is only one grade available and it cannot be determined if it is clinical, pathological, or after neo-adjuvant therapy * Grade checked “not applicable” on CAP Protocol (if available) and no other grade information is available




NAACCR #3844


Code Description
1 WHO Grade I : Circumscribed tumors of low proliferative potential associated with the possibility of cure following resection
2 WHO Grade II: Infiltrative tumors with low proliferative potential with increased risk of recurrence
3 WHO Grade III: Tumors with histologic evidence of malignancy, including nuclear atypia and mitotic activity, associated with an aggressive clinical course
4 WHO Grade IV: Tumors that are cytologically malignant, mitotically active, and associated with rapid clinical progression and potential for dissemination
L Stated as “low grade” NOS
H Stated as “high grade” NOS
A Well differentiated
B Moderately differentiated
C Poorly differentiated
D Undifferentiated, anaplastic
9 Grade cannot be assessed (GX); Unknown