Summary Stage 2018: Appendix (including NET)

Summary Stage 2018

Notes

**Appendix (including Neuroendocrine tumors)** C181 C181 Appendix **Note:** The following sources were used in the development of this schema * SEER Extent of Disease 1988: Codes and Coding Instructions (3rd Edition, 1998) (https://seer.cancer.gov/archive/manuals/EOD10Dig.3rd.pdf) * SEER Summary Staging Manual-2000: Codes and Coding Instructions (https://seer.cancer.gov/tools/ssm/) * Collaborative Stage Data Collection System, version 02.05: https://cancerstaging.org/cstage/Pages/default.aspx * Chapter 19 *Appendix – Carcinoma*, in the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing. Used with permission of the American College of Surgeons, Chicago, Illinois. * Chapter 32 *Neuroendocrine Tumors of the Appendix*, in the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing. Used with permission of the American College of Surgeons, Chicago, Illinois.

NAACCR Item

NAACCR #764
SS2018 Description
0 In situ, intraepithelial, noninvasive - Acellular mucin or mucinous epithelium may invade into the muscularis propria - (Adeno) carcinoma, noninvasive, in a polyp or adenoma - Low-grade appendiceal mucinous neoplasm confined by the muscularis propria (LAMN)
1 Localized only (localized, NOS) - Confined to appendix, NOS - Confined to polyp, NOS - Extension through wall, NOS - Invasion through muscularis propria - Lamina propria - Mucosa (intramucosal, NOS) - Muscularis mucosae - Non-peritonealized pericolic tissues invaded - Perimuscular tissue invaded - Submucosa - Subserosa - Transmural, NOS - Wall, NOS
2 Regional by direct extension only - Abdominal wall - Adherent to other organs or structures - Adjacent tissue(s), NOS - Connective tissue - Fat, NOS - Greater omentum - Mesenteric fat - Mesentery - Mesoappendix - Pericolic fat - Retroperitoneum - Serosa (mesothelium) (visceral peritoneum) - Small intestine - Tumor found in adhesion(s) if microscopic examination performed
3 Regional lymph node(s) involved only - Cecal + Anterior (prececal) + Posterior (retrocecal) + Right colic - Colic, NOS - Epicolic (adjacent to bowel wall) - Ileocolic - Mesenteric, NOS - Mesocolic, NOS - Paracolic/pericolic - Regional lymph node(s), NOS + Lymph node(s), NOS
4 Regional by BOTH direct extension AND regional lymph node(s) involved - Codes (2) + (3)
7 Distant site(s)/lymph node(s) involved - Distant site(s) (including further contiguous extension) + Adrenal (suprarenal) gland + Bladder + Diaphragm + Fallopian tube + Fistula to skin + Gallbladder + Intraperitoneal spread/peritoneal metastasis + Kidney + Liver + Other segment(s) of colon/rectum via serosa + Ovary + Ureter + Uterus - Distant lymph node(s), NOS + Inferior mesenteric + Superior mesenteric - Distant metastasis, NOS + Carcinomatosis + Distant metastasis WITH or WITHOUT distant lymph node(s)
9 Unknown if extension or metastasis
(1) Fritz AG, Ries LAG (eds). **SEER Extent of Disease 1988: Codes and Coding Instructions (3rd Edition, 1998)**, National Cancer Institute, NIH Pub. No. 98-2313, Bethesda, MD, 1998 (2) Young JL Jr, Roffers SD, Ries LAG, Fritz AG, Hurlbut AA (eds.). **SEER Summary Staging Manual-2000: Codes and Coding Instructions**, National Cancer Institute, NIH Pub. No. 01-4969, Bethesda, MD, 2001. (3) Collaborative Stage Work Group of the American Joint Committee on Cancer. **Collaborative Stage Data Collection System User Documentation and Coding Instructions, version 02.05.** American Joint Committee on Cancer (Chicago, IL) (4) Gress, D.M., Edge, S.B., Gershenwald, J.E., et al. **Principles of Cancer Staging.** In: Amin, M.B., Edge, S.B., Greene, F.L., et al. (Eds.) AJCC Cancer Staging Manual. 8th Ed. New York: Springer; 2017: 3-30 (5) Overman, M.J., Jessup, J.M., et al. **Appendix – Carcinoma**. In: Amin, M.B., Edge, S.B., Greene, F.L., et al. (Eds.) AJCC Cancer Staging Manual. 8th Ed. New York: Springer; 2017: 237-250 (6) Woltering, E.A., Bergsland, E.K., et al. **Neuroendocrine Tumors of the Appendix**. In: Amin, M.B., Edge, S.B., Greene, F.L., et al. (Eds.) AJCC Cancer Staging Manual. 8th Ed. New York: Springer; 2017: 389-394